- STS9 (Sound Tribe Sector 9)
- Sacha Sacket
- Salim Nourallah
- Sally Shapiro
- Salvador Santana Band
- Sam Prekop
- Sam Sparro
- Sanctus Real
- Sappy Bell
- Sarah Bettens
- Sasha Dith
- Saving Jane
- Saxon
- Scanners
- Scars of Tomorrow
- Scary Kids Scaring Kids
- Scissor Sisters
- Scissors For Lefty
- Scotch Greens
- Scott Fisher
- Scott Stapp
- Scum
- Scum Of The Earth
- Sea Wolf
- Searching For Skylines
- Sebastian Bach
- Sebastien Schuller
- Secondhand Serenade
- Secret & Whisper
- Secretary Bird
- Seemless
- Seether
- Self Against City
- Sepultura
- Set Your Goals
- Seven Channels
- Sevendust
- Seventh Day Slumber
- Seventh Star
- Shadows Fall
- Sharkey
- Shauna Burns
- Shelter
- Sherwood
- Shiny Toy Guns
- Shivaree
- Shocking Pinks
- Shout Out Louds
- Showbread
- Shutdown
- Shyko
- Si Se
- Sia
- Sick City
- Sick Puppies
- Sick of It All
- Sierra Swan
- Sigur Ros
- Sikth
- Silent Civilian
- Silverchair
- Silverstein
- Silversun Pickups
- Simple Kid
- Sinai Beach
- Since 04
- Single Frame
- Sink To See
- Sixpence None the Richer
- Sixx:A.M.
- Skillet
- Skinny Puppy
- Slapbak
- Slash's Snakepit
- Slave Driver
- Sleater-Kinney
- Sleepthief
- Sleepytime Gorilla Museum
- Slick Shoes
- Slider's Fault
- Slow Six
- Slunt
- Smog
- Smoosh
- Snakes & Music
- Snapcase
- Snowden
- So They Say
- Sohodolls
- Soilent Green
- Someone Still Loves You Boris Yeltsin
- Sons & Daughters
- Sonya Kitchell
- Sophie B. Hawkins
- Sore
- Soul Kid #1
- Soulidium
- Soundpool
- South
- Southern Backtones
- Sparta
- Spiraling
- Spitalfield
- Spoken
- Spoon
- Spotty Dogg
- Squirtgun
- St Germain
- St. Vincent
- Stabbing Westward
- Stalking Tom
- Staple
- Starflyer 59
- Starlight Mints
- Stars
- Stars of Track and Field
- Starsailor
- Static Age
- Stefy
- Stellar Kart
- Stereophonics
- Steve Bertrand
- Stillbirth
- Stolen Babies
- Story Of The Year
- Straight Line Stitch
- Strapping Young Lad
- Strata
- Straylight Run
- Street Drum Corps
- Streetlight Manifesto
- Stretch Arm Strong
- Strike Anywhere
- Strung Out
- Styx
- Subseven
- Suburban Kids With Biblical Names
- Suburban Legends
- Suffocation
- Sugarcult
- Suicide City
- Suit of Lights
- Sullivan
- Sunday Drivers
- Supagroup
- Super Black Market
- Superchick
- Supercreep
- Supergrass
- Superjoint Ritual
- Supersystem
- Suzanne Vega
- Svoy
- Symphony X
